| abstract |
An irinotecan liposome preparation, a preparation method, and use. The irinotecan liposome comprises irinotecan and liposome carriers, and internal aqueous phases located inside a liposome membrane and an external aqueous phase located outside the liposome membrane, the irinotecan is encapsulated in the internal aqueous phases, and a sulfonate gradient exists between the internal aqueous phases inside the liposome membrane and the external aqueous phase outside the liposome membrane. The liposome takes monovalent sulfonate and disulfonate as the internal water phases, encapsulates the irinotecan in the form of insoluble sulfonate and disulfonate in the aqueous phases of the liposome, and has a good sustained-release effect. |