http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3874271-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4dd0b43956b645785df031c94acf1b3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-60 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H50-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57407 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate | 2019-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba9c4495ded55ee32fe14512134697ee |
| publicationDate | 2021-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3874271-A1 |
| titleOfInvention | Method for predicting the effectiveness of treatments for cancer patients |
| abstract | A method for predicting whether a patient with cancer is likely to respond to a particular treatment. The method comprises measuring a value indicative of a level of each of the biomarkers ATM, CHEK2, TP53, MDM2, PPM1D, SIAH1, HIPK2 and WSB1 and/or any of their paralogs, isoforms, or genes with similar biological functions within a sample from the patient; calculating a total value using a weighted sum of the measured values; wherein each biomarker value has an associated weight; comparing the total value to a threshold value and when it is determined that the total value is below the threshold value, determining that the patient is likely to respond to the treatment. Alternatively, the method comprises applying a model comprising a set of coupled ordinary differential equations defining the rate of change of a plurality of biomarkers to predict a plurality of output values for each of the biomarkers for the treatment; selecting a biomarker from the plurality of biomarkers; comparing the output value for the selected biomarker to an associated threshold value for the selected biomarker; and when the output value for the selected biomarker is below the associated threshold value, determining that the patient is likely to respond to the treatment; wherein the plurality of biomarkers include p53, ATM, CHK2, SIAH1, HIPK2, WIP1 and MDM2. |
| priorityDate | 2018-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 103.