abstract |
The present disclosure provides compounds represented by Formula (I): wherein R la , R lb , R 2a , R 2b , R 3a , R 3b , R 4 , A, L, X, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat cancer or any other disease, condition, or disorder that is responsive to degradation of MDM2 protein. |