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filingDate 2019-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a42b7452705cd140ee02230811393c54
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publicationDate 2021-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3837277-A1
titleOfInvention Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease
abstract Described herein are recombinant Newcastle disease viruses ("NDVs") comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a respiratory syncytial virus ("RSV") F protein or human metapneumovirus ("hMPV") F protein. Also described herein are recombinant NDVs comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a chimeric F protein, wherein the chimeric F protein comprises (i) an RSV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains; or (ii) an hMPV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains. The recombinant NDVs and compositions thereof are useful for the immunizing against RSV or hMPV as well as the prevention of RSV disease or hMPV disease.
priorityDate 2018-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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