| abstract |
Disclosed is a recombinant dust mite allergen protein composition, comprising a recombinant dust mite type I allergen DP1 and DF1 proteins and a recombinant dust mite type II allergen DP2 and DF2 proteins, wherein same are respectively mixed in an activity ratio of 1:1:1:1 or mixed in a mass ratio of (1-5):(1-20):(1-10):(1-20). Compared to existing products, (1) the recombinant allergens have the advantages of a high purity and a controllable quality, etc.; (2) the recombinant proteins have better specificity; and (3) compared with the natural extract, the composition has better immunogenicity, reduces the risk of serious allergic side reactions and improves the effect of a desensitization treatment. In addition, the recombinant allergen composition of the present invention not only has a better activity than the natural allergen protein in the same proportions, but also has a higher activity than the corresponding natural single component when compared with the single component. |