| abstract |
The present invention is directed to a method for producing a bioartificial and primarily acellular construct based on fibrin, wherein a mixture of fibrinogen-containing and thrombin-containing cell-free compositions are applied to a surface and then pressurized over a large area. In a further aspect, the present invention is directed to such bioartificial, acellular constructs based on fibrin and obtained according to the invention with improved biomechanical properties, as well as their use in the field of implantology, cartilage replacement or tissue replacement. |