| abstract |
Provided herein are antigenically stealthed HSV particles, and methods of use of the antigenically-stealthed HSV particles. In one aspect of the invention, a retargeted herpes simplex virus (HSV) particle is provided, the HSV particle comprising a glycoprotein modified to reduce or eliminate recognition by antibodies that interfere with vims infection. In one embodiment, the modified glycoprotein is an antigenically-modified glycoprotein B (gB) and/or an antigenically-modified glycoprotein D (gD) protein. Further provided is a method of treating a patient having a cancer, comprising administering to the patient an amount of the retargeted HSV particles. |