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filingDate 2015-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2021-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3808841-A1
titleOfInvention Method for preparation of thrombin
abstract The present invention is directed to methods for the production of thrombin from a source of prothrombin using a given BaSO<sub>4</sub> reagent as an adsorbent of prothrombin as well as methods for evaluating the suitability of a given BaSO<sub>4</sub> reagent for use in preparation of thrombin. In at least one embodiment, the method includes contacting a sample of the given BaSO<sub>4</sub> reagent with a source of prothrombin to obtain BaSO<sub>4</sub>-adsorbed prothrombin, and subsequently evaluating the pro-coagulant activity of the BaSO<sub>4</sub>-adsorbed prothrombin. In another embodiment, the method includes the step of evaluating relative to the pro-coagulant activity of normal mammalian plasma.
priorityDate 2015-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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