http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3805380-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55eb7068b1cb3f682aab030766734ef6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-07049 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15022 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-07049 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
| filingDate | 2019-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7202844dd7080cc279270cad9bc811a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d24df69800bb862480ad7364219614d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_731f0564f8de198f4223a0f651492dc6 |
| publicationDate | 2021-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3805380-A1 |
| titleOfInvention | Improved thermostable viral reverse transcriptase |
| abstract | The present invention provides engineered reverse transcriptase enzymes that afford beneficial improvements in thermal stability, processivity, cDNA yields and elimination of secondary enzymatic activity. The present invention also provides methods for amplifying template nucleic acids using such reverse transcriptase enzymes. This invention addresses deficiencies in the current state of the art reverse transcriptase enzymes in RNA detection and analysis including deficiencies in detection sensitivity, specificity, side enzyme activities, enzyme stability and synthesis capacity, especially when using template nucleic acids ranging in length, secondary structure and nucleotide content. The invention provides variants of the equine infectious anemia virus (EIAV) RT with mutations that eliminate RNase H activity, substitutions in the minor groove binding track (MBGT) of the thumb domain or substitutions in the RT's connection domain. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3997218-A4 |
| priorityDate | 2019-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.