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publicationDate 2021-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3803398-A1
titleOfInvention Modified nucleobases with uniform h-bonding interactions, homo- and hetero-basepair bias, and mismatch discrimination
abstract Described herein are divalent nucleobases that each binds two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone, such as in a γ-peptide nucleic acid (γPNA). Also provided are genetic recognition reagents comprising one or more of the divalent nucleobases and a nucleic acid or nucleic acid analog backbone, such as a γPNA backbone. Uses for the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
priorityDate 2018-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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