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filingDate 2019-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17e026981e7bf746c1d91e6928a7f50f
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publicationDate 2021-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3802852-A1
titleOfInvention Engineered cyclic peptides
abstract An engineered cyclic peptide provides structural constraints to resist non-specific degradation in the human body and includes environment- specific cleavage sites to allow release of a linearized peptide upon reaching a target environment. The linearized peptide can include a reporter molecule or a bioactive therapeutic such that the cyclic peptide is essentially inactive at administration and in circulation but becomes reactive only upon exposure to target- specific environmental factors such as a specific combination of differentially-expressed proteases associated with a target tissue or disease state. The peptides can include tuning that modulate distribution by targeting the particle to specific tissue, bodily fluids, or cell types.
priorityDate 2018-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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