abstract |
The present invention relates to a pharmaceutical composition comprising CCN5 as an active ingredient, for preventing or treating retinal diseases. CCN5 according to the present invention prevents fibrotic changes, caused by TGF-β, EEF, or anti-VEGF drugs, in retinal pigment epithelial cells. In addition, CCN5 recuperates the morphological or functional damage, caused by fibrotic changes, of retinal pigment epithelial cells to the level of normal cells. Therefore, the composition comprising CCN5 as an active ingredient can be advantageously utilized for preventing or treating retinal diseases. |