| abstract |
A transgenic mouse which is engineered by one or more genetic modifications that reduce expression of endogenous Adam6a and Adam6b genes in a male mouse compared to a male mouse without said one or more genetic modifications, which mouse comprises in its genome only one exogenous Adam6 transgene, and expresses an ADAM6 protein comprising at least 90% sequence identity to SEQ ID NO:1 or SEQ ID NO:2, which Adam6 transgene is functional in a male mouse. |