| abstract |
A device for separation of a biological sample into a first phase and a second phase, said device comprising:a container including at least a first portion have a first diameter, a second portion having a second diameter, and a third portion having a third diameter;an inlet located adjacent the first portion, said inlet configured for receiving the biological sample;an outlet located adjacent the third portion wherein the second portion is located between the first and third portion;a separator located within the container and disposed between the inlet and the outlet, the separator for separating the biological sample into the first phase and the second phase; anda member for creating a pressure gradient across the separator to increase a rate of movement of the biological sample through the separator such that the first phase exits the separator and the outlet prior to the second phase, and wherein the first, second, and third diameters progressively decrease in size with the first diameter being the largest in size and the third diameter being the smallest in size. |