http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3781949-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_627acf3b3095acb9831b527825a6ba5f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2400-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-56 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-581 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 |
| filingDate | 2019-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e4f4ef014b7238ff64f39f90299f278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd4afd6a18c0cf2e5c0674abbcc5ed28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f6b19a4c99d3cb597694e1c53a4549a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ee8ab7d09744e39c5dca1161d22eb18 |
| publicationDate | 2021-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3781949-A1 |
| titleOfInvention | Methods and kits for detecting o-glcnac sites using b3galnt2 and ogt |
| abstract | In an in vitro method of determining the modification degree of O-GlcNAc in a biological sample, a first sample is treated with B3GALNT2 to incorporate a GalNAz into closed O-GlcNAc sites in the sample, labeled using click chemistry to form labeled closed O-GlcNAc sites, and the labeled closed O-GlcNAc sites in the first sample are detected (corresponding to the number of closed O-GlcNAc sites in the biological sample). A second, duplicate sample is treated with OGT to O-GlcNAcylate open O-GlcNAc sites in the sample to convert the open O-GlcNAc sites to closed O-GlcNAc sites, and treated with B3GALNT2 to incorporate GalNAz into the closed O-GlcNAc sites. The second sample is labeled using click chemistry to form labeled closed O-GlcNAc sites (corresponding to the total number of O-GlcNAc sites in the biological sample). The number of closed O-GlcNAc sites and total O-GlcNAc sites in the biological sample are compared to determine the modification degree of O-GlcNAc. |
| priorityDate | 2018-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.