| abstract |
Provided are a cationic lipid having improved intracellular kinetics, a lipid membrane structure containing same, and use thereof. n A cationic lipid represented by the formula (1)n n(in the formula (1), nR 1a and R 1b are each independently an alkylene group having 1 - 6 carbon atoms, nX a and X b are each independently a non-cyclic alkyl tertiary amino group having 1 - 6 carbon atoms and one tertiary amino group, or a cyclic alkylene tertiary amino group having 2 - 5 carbon atoms and 1 - 2 tertiary amino groups, nR 2a and R 2b are each independently an alkylene group or an oxydialkylene group each having not more than 8 carbon atoms, nY a and Y b are each independently an ester bond, an amide bond, a carbamate bond, an ether bond or a urea bond, nZ a and Z b are each independently a divalent group derived from an aromatic compound having 3 - 16 carbon atoms and at least one aromatic ring, and optionally having a hetero atom, and nR 3a and R 3b are each independently a residue derived from a reaction product of a liposoluble vitamin having a hydroxyl group, and succinic anhydride or glutaric anhydride, or a residue derived from a reaction product of a sterol derivative having a hydroxyl group, and succinic anhydride or glutaric anhydride, or an aliphatic hydrocarbon group having 12 - 22 carbon atoms). |