| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d4340f8dcf189faf8e2ecf7284c3b2e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0041 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-33303
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-333
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-33337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-335
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-4037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6923 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L71-00 |
| filingDate |
2019-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fb34318187a8f7072f2c0baf3669d24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0edb43dd79e97fc955eb4252829d424
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fcdd933b5ba000de1b642fba1ea3941 |
| publicationDate |
2021-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3766981-A1 |
| titleOfInvention |
Cationic poloxamers and their use in transduction |
| abstract |
The invention relates to a method for the enhancement of the transduction of a target cells by a viral vector using a cationic block-copolymer introduced as an additive alone or formulated with nanoparticles. The method comprises a step of contacting a target cells with viruses and a cationic block co-polymer. The structure of this additive incorporates both hydrophilic and hydrophobic regions which represents different areas in the backbone of the polymer. This polymeric construction is ended by cationic chemical functions which contribute to further enhance the viral transduction. The invention also relates to new cationic poloxamers that can be used in the method of the invention. Furthermore, another embodiment of the present invention relates to the colloidal stabilization of iron-based nanoparticles using these polymers and their use in increasing transduction efficiency. |
| priorityDate |
2019-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |