| abstract |
The present invention provides an aqueous suspension pharmaceutical preparation comprising the following (1) to (4) :(1) (3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl}hexahydro-4,7-methano-2H-isoindole-1,3-dione (Compound 1), a pharmaceutically acceptable acid addition salt thereof, or a mixture thereof,(2) xanthan gum,(3) a dispersant, and(4) water,which can inhibit rapid dissolution and absorption of the drug even when the pharmaceutical preparation is administered orally and reduce the risk of unexpected side effects caused by the temporary increase in blood level of the drug. |