abstract |
The present invention relates to a novel botulinum neurotoxin (BoNT) Heavy Chain Binding domain (Hc/TAB) adapted to synergistically bind to a synaptotagmin (Syt) receptor, a synaptic associated vesicle 2 (SV2) receptor and a ganglioside (Gang) receptor, as well as polypeptides comprising said novel Hc/TAB, vectors encoding said polypeptides, and uses thereof. |