| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb9c6b40161bafe7bd55f0b4defcea04 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J21-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J13-007 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 |
| filingDate |
2019-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d215db0e86eec95bae03ea28458ec8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_563077d61e14e1222581f66d6d8fce28 |
| publicationDate |
2020-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3752517-A1 |
| titleOfInvention |
Cyclin-dependent kinase degraders and methods of use |
| abstract |
The present application provides bifunctional compounds of Formula (Ia): (Ia), or an enantiomer, diastereomer, stereoisomer, or pharmaceutically acceptable salt thereof, which act as protein degradation inducing moieties for one or more of cyclin-dependent kinase 8 (CDK8) and cyclin-dependent kinase 19 (CDK19). The present application also relates to methods for the targeted degradation of CDK8 and/or CDK19 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to CDK8 and/or CDK19 which can be utilized in the treatment of disorders modulated by CDK8 and/or CDK19. |
| priorityDate |
2018-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |