| abstract |
Provided are a chimeric antigen receptor and an application thereof; said chimeric antigen receptor contains a domain which identifies any one of, or a combination of at least two of, the Plasmodium protein VAR2CSA, a protein tag on Plasmodium protein VAR2CSA, or a compound capable of labeling the Plasmodium protein VAR2CSA. The chimeric antigen receptor can identify the VAR2CSA protein or the recombinant protein (rVAR2) of any one of, or at least two of, the domains of the VAR2CSA protein which can bind to placental chondroitin sulfate (pl-CSA). The VAR2CSA protein or rVAR2 protein is capable of targeting several different types of tumor cells by means of binding to the pl-CSA on the surface of the tumor cell. |