http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3738614-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_538734c56518e3e6873170637f3453da |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6855 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 |
| filingDate | 2019-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfc3b3e434bdb1818b139218168c22e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c4fff86732a3eb6114e0a627975edef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f82478f4aac441500d0661647da8ee78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c889fb4ef2d440e4b16ef11753c9b7d9 |
| publicationDate | 2020-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3738614-A1 |
| titleOfInvention | Methods for producing homogeneous antibody drug conjugates |
| abstract | A method is provided for producing antibody conjugates having homogeneous payload antibody ratio. The method comprises: (i) providing separate fractions of heavy chains and light chains of an antibody or a fragment thereof both having interchain thiols; (ii) separately conjugating a payload to the interchain thiols of the heavy chains or to the interchain thiols of the light chains or to both; and (iii) assembling the resulting heavy chains with the resulting light chains by mixing them to form antibody conjugates. A homogeneous composition is obtained comprising antibody conjugates of the same payload antibody ratio, wherein the antibody in the antibody conjugate has its native amino acid sequence without modifications and with the sugar groups of the original antibody. |
| priorityDate | 2019-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1148.