| abstract |
The present invention relates to a compound of general formula (I), wherein R 1 is OCH 2 CH 2 OCH 3 or OCH 3 , R' 1 is H or OH, R 2 is Cl, F, Br or I, with the proviso that when: R 1 is OCH 2 CH 2 OCH 3 then R' 1 is H, R 1 is OCH 3 then R' 1 is OH, its pharmaceutically acceptable salts and/or optical isomers, tautomers, solvates or isotopic variations thereof. The invention also relates to said compounds for use in the treatment of cancer, namely solid tumor cancer, and preferably those selected from melanoma, colon, lung, pancreas, kidney, Merkel carcinoma, squamous cell carcinoma, prostate, breast and bladder. The invention also relates to a pharmaceutical composition comprising said compounds. |