| abstract |
Described herein are compositions and methods for the modulation of T-cell tolerance, which can be upregulated or down regulated by concurrent enhancement or inhibition of CEACAM1/TIM3 interactions. As described herein, the discovery that CEACAM1 is a direct ligand of TIM3 andvice versahas been shown incisand intrans.In addition, as demonstrated herein, CEACAM1 and TIM3 are co-regulated during the course of T-cell activation. |