| abstract |
The present invention provides methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, particularly after intravenous administration, and compositions comprising these RNA lipoplex particles. The present invention also provides methods for preparing RNA lipoplex particles in a manner consistent with industrial GMP. In addition, the present invention relates to methods and compositions for storing RNA lipoplexes without substantial loss of product quality and, in particular, without substantial loss of RNA activity. |