| abstract |
Disclosed are methods of treating a disease associated with ciliopathy, comprising administering to an individual in need thereof an effective amount of a compound targeting at least one G protein-coupled receptor. identifying therapeutic agents for treating a disease characterized by ciliopathy, comprising obtaining an animal model system of ciliopathy for testing a putative therapeutic agent, administering to the animal a disrupting agent, treating said animal with the agent putative therapeutic, to compare the measurable phenotype of the treated animal with that of the untreated animal and to identify the therapeutic target for the treatment of ciliopathy, when the measurable phenotype of the treated animal is reduced compared to that of the untreated animal. |