| abstract |
The present invention provides devices, systems, and methods for treating dementia or Alzheimer's disease in a subject in need thereof. In one example, chronic visual stimuli having a frequency of about 30 Hz to about 50 Hz, and more particularly about 40 Hz, are non-invasively administered to the subject to cause gamma oscillations in multiple brain regions of the subject , including the prefrontal cortex (PFC) and the hippocampus. Driven gamma oscillations modulate neuronal activity across multiple brain regions (eg, facilitate functional binding of neural networks at low gamma frequencies) to induce various neuroprotective effects (eg, amyloid plaque enhancement and hyperphosphorylation of Tau) and reduce neurodegeneration. Neuronal activity mediated by chronic visual stimuli reduces an immune response to microglia and improves aberrantly-modified genes and proteins involved in membrane trafficking, intracellular transport, synaptic function, neuroinflammation, and immune response. damage to the DNA. A behavior modification including improved learning and memory is observed. |