| abstract |
In accordance with aspects, the present invention is directed to methods and compositions (eg, kits) for detecting RNA-associated non-ATG proteins in a subject (e.g., a subject having or suspected of having a disease associated with the translation of RAN protein, eg amyotrophic lateral sclerosis (ALS) and / or frontotemporal dementia (FTD), or spinocerebellar ataxia type 36 (SCA36), or other diseases that produce poly (PR), poly (GR) or poly (GP) RAN proteins According to some embodiments, the methods provided by the present invention include the detection of one or more RAN proteins in a biological sample obtained from one subject by an electrochemiluminescence-based immunoassay using one or more antibodies directed against RAN proteins According to some embodiments, the invention relates to kits comprising one or more anti-RAN antibody and an electrochemiluminescence-based immunoassay plate and / or reagents. |