| abstract |
The present invention, in certain corresponding embodiments, relates to ectodomain binding inhibitory compositions of a Roundabout family (Robo) receptor and the use thereof for downregulation of mediated signaling. by the Robo receivers. In particular, the present invention relates to fragments that bind to an Ig-type Robo receptor ectodomain and prevent its dimerization, thereby inhibiting the activity of the Robo receptor. |