| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d54adcccfe94ca903946779172afb5d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac9442e962452275a63c777abad46223 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-03 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-723
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70503 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate |
2018-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c198fcae52f37ffb5e484071daee50a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fcb8a5c6cab16b54022e9001703dc11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_146087a8903a23222eddab24e90fd41b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf230e0cf0c08c4d1715220f582f266f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c57ed9741861b7349ccc65cae65c03ea |
| publicationDate |
2020-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3672982-A1 |
| titleOfInvention |
Screening assays, modulators and modulation of activation of receptor for advanced glycation end-products (rage) |
| abstract |
The invention relates to a method for screening candidate agents for their ability to modulate RAGE activity, wherein such RAGE activity is induced by an active co-located GPCR, the method comprising the steps of: contacting a RAGE polypeptide with a GPCR polypeptide in the presence of a candidate agent wherein the GPCR polypeptide is constitutively active and / or is activated by the addition of an agonist, a partial agonist or an allosteric modulator of this GPCR; and detecting whether the candidate agent is a modulator of RAGE ligand independent RAGE activation by a co-located GPCR activated by detection of an effect indicative of modulation of RAGE activation by the presence of the candidate agent and / or by detecting a RAGE dependent signaling that is modulated by the presence of the candidate agent. |
| priorityDate |
2017-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |