http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3672540-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_503976932bc37df06280e476ef860ceb |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0085 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F9-0017 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1824 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F9-00 |
| filingDate | 2018-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5e6f6ec6bf49604a99684ec676f826d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43ccee0c7a0d3633ff9ad7cf03d2c7c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3d7286adab39660c46f571735f1b11b |
| publicationDate | 2020-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3672540-A1 |
| titleOfInvention | Slippery micropropellers penetrate the vitreous humor |
| abstract | The intravitreal administration of therapeutic and imaging nanoparticles promises significant potential applications in the field of eye medicine, while the slow and random passive diffusion of particles into the vitreous invites new strategies for rapid delivery to a target site in the field of eye medicine. the back of the eye. Here we present the first microparticles that actively propel the vitreous humor (the vitreous body) and reach the retina in porcine eyes. Sliding helical propellers are constructed by the combination of a glancing angle deposition technique and the melting of the slippery liquid layer. Magnetic propulsion in the vitreous humor is based on the adapted size of the propellant to the collagen network of the vitreous, and on the non-stick coating of the bundles of collagen fibers. Clinical Optical Coherence Tomography (CTCT) has observed moving micropropellants sliding through the vitreous humor towards the macular area on the retina. Sliding micro-propellers made massive movements controllable to the retina in 30 min, while exerting the displacement distance above one centimeter. Therefore, the injection of the slidable micropropellants, the magnetically controllable propulsion into the vitreous, and the optical coherence tomography imaging technique constitute an intact process for rapid targeted ocular administration, providing a promising approach to ophthalmic applications screws. |
| priorityDate | 2017-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 219.