http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3666759-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 |
| filingDate | 2018-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3666759-A1 |
| titleOfInvention | Preparation of 6-halo-2-(haloalkyl)-3-acylpyridines and intermediates therefor |
| abstract | The present invention relates to a process for preparing compounds of formula (I)wherein R represents C<sub>1</sub>-C<sub>2</sub>-alkyl and X represents chlorine or bromine, by reacting a compound of formula (II)wherein R is defined as in formula (I), in a first step A) with a dehydroxyhalogenation agent selected from COCl<sub>2</sub>, (COCl)<sub>2</sub>, cyanuric chloride, SOCl<sub>2</sub>, SO<sub>2</sub>Cl<sub>2</sub>, PCl<sub>3</sub>, PCl<sub>5</sub>, POCl<sub>3</sub>, PBr<sub>3</sub>, SOBr<sub>2</sub>and SO<sub>2</sub>Br<sub>2</sub>to arrive at a compound of formula (III)wherein X and R are defined as in formula (I), and the compound of formula (III) is reacted in step B) with a malonate of formula (IV)wherein R<sup>1</sup>represents C<sub>1</sub>-C<sub>6</sub>-alkyl, C<sub>2</sub>-C<sub>6</sub>-alkenyl, C<sub>2</sub>-C<sub>6</sub>-alkynyl, C<sub>3</sub>-C<sub>8</sub>-cycloalkyl or benzyl; in presence of a base and a magnesium compound to arrive at a compound of formula (V)wherein X and R are defined as in formula (I); and R<sup>1</sup>is defined as in formula (IV); and decarboxylating the compound of formula (V). Optionally the resulting compound of formula (I) is further reacted to a triazole derivative of formula (VIII)It further relates to the compounds of formula (V). |
| priorityDate | 2018-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 303.