| abstract |
The present invention provides methods of treating an HPN subject, comprising administering to a subject a therapeutically effective amount of a C5 complement component (C5) inhibitor, a complement component inhibitor, and C3 (C3), or a complement Factor B inhibitor (CFB) in combination with a therapeutically effective amount of a small molecule complement Factor D (CFD) inhibitor of formula I or formula II, or its pharmaceutically acceptable salt. |