| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e59c33cd14368512f9dfb0a821d9003e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-236
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-06 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08K5-0025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08K5-1545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-735
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L5-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 |
| filingDate |
2018-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab7ee4ac00adf0f1bf304852a21ec71e |
| publicationDate |
2020-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3659632-A1 |
| titleOfInvention |
Post-crosslinking partial degradation of amide crosslinked hydrogels |
| abstract |
The present invention provides a method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules at a concentration C<sub>final</sub>(mg/mL), said method comprising the steps of: a) crosslinking a glycosaminoglycan having a molecular weight of above 700 kDa in conditions so as to provide a glycosaminoglycan hydrogel crosslinked by amide bonds and having a C<sub>min</sub>(mg/mL) that is above C<sub>final</sub>/2, wherein C<sub>min</sub>is the concentration of gel-form glycosaminoglycan in the gel when fully swollen in physiological buffer; b) subjecting the hydrogel from step a) to post-crosslinking degradation of the glycosaminoglycan backbone, thereby reducing the C<sub>min</sub>of the hydrogel to a value that is below C<sub>final</sub>/2; and c) formulating the partially degraded hydrogel obtained from step b) to form an injectable hydrogel composition having a concentration of glycosaminoglycan molecules of C<sub>final</sub>(mg/mL). |
| priorityDate |
2018-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |