| abstract |
Inhibitors, such as antibodies, and antigen-binding fragments thereof, which selectively bind to LTBP1-TGFβ1 and / or LTBP3-TGFβ1 complexes. The invention also provides methods of using these inhibitors to, for example, inhibit TGFβ1 activation, and treat subjects with TGFβ1-related disorders, such as fibrotic conditions. The invention also relates to methods of selecting a TGFβ1 inhibitor specific for the dependent or context-independent isoform for a subject in need thereof. |