| abstract |
The present invention relates to bifunctional compounds which are useful in the degradation and (inhibition) of the androgen receptor. In particular, the present invention relates to compounds which contain at one end a VHL ligand which binds to ubiquitin ligase, and at the other end a fragment which binds to the androgen receptor so that the androgen receptor is placed. near ubiquitin ligase to effect degradation (and inhibition) of the androgen receptor. The present invention has a wide range of pharmacological activities associated with the compounds of the present invention, compatible with the degradation / inhibition of the androgen receptor. |