abstract |
The present invention relates to chimeric receptors which comprise (i) an input detection domain, (ii) a transmembrane domain, (iii) a cleavage site and (iv) an effector domain, the effector domain comprising or consisting of a first domain of a multi-domain protein, the multidomain protein being a protein that is capable of binding RNA to form a protein / RNA complex that is capable of targeting a target nucleic acid, and the effector domain only not being able to form an RNA / protein complex that is able to target the target nucleic acid. The present invention also relates to nucleic acids and vectors encoding such chimeric receptors; kits comprising such chimeric receptors; and methods of using such chimeric receptors. |