| abstract |
The present invention provides specific, selective and irreversible inhibitors and activity-based probes (ABPs) of KLK7. These ABPs and inhibitors are useful as new treatments for skin desquamating and/or inflammatory disorders, as new antiinflammatory agents, new anti-neurodegenerative agents and as new anticancer therapeutics. Also provided are pharmaceutical combinations of the compounds according to the invention with inhibitors of KLK5 for use in the treatment of said diseases and disorders. The invention also provides cosmetic compositions for skin application, preferably for the improvement of an undesirable skin condition. The compounds of the present invention can also be used for thein vitroandin vivomolecular diagnosis of skin disorders characterized by abnormal desquamation and/or inflammation, inflammatory diseases, neurodegenerative diseases or cancer. |