| abstract |
The present invention relates to substituted pyrazolo-quinazoline derivatives that modulate choline kinase (ChoK) activity. The compounds of the present invention are therefore useful in the treatment of diseases caused by impaired choline metabolism, including cancer, cell proliferative disorders, infectious diseases of different origins, immune system disorders and neurodegenerative disorders. The present invention also relates to methods of preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases employing pharmaceutical compositions comprising these compounds. |