| abstract |
The present invention generally relates to the generation of induced pluripotent stem cells (iPSCs). In particular aspects, the present invention generally relates to methods of generating iPSC from non-pluripotent cells, such as aged somatic cells, wherein iPSCs are characterized by improved genomic stability, improved response to damage. DNA, increased ZSCAN10 expression, reduced GSS expression, and / or increased reprogramming efficiency. |