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publicationDate 2020-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3651702-A1
titleOfInvention Intravascular stent, especially for coronary vessels
abstract The intravascular stent is characterized in that the cuts (1) forming the segmented patterns of its structure at the same time form the elongate lines (2) of the main segment (3) located around the longitudinal axis of the stent (4) and are connected by means of U-shaped connecting elements (5), thus creating around the longitudinal axis (4) of the stent a geometrical pattern resembling a meander of soft edges, and the two curves (6) in crescent shape or the letter "V" with rounded edges together with the oval plate (8) form a connecting segment (7) for connecting to the connecting elements (5) of the elongated lines (2) of the main segment (3), each subsequent main segment (9) being a specular reflection of the preceding segment (10), and in that the curves (6) of the crescent-shaped connecting element (7) or the letter "V" "with rounded edges (6) are a mutual specular reflection with respect to the than oval (8) of the connecting segment (7). The end segments of the stent are the main end segments (12), each second outer connecting member (5) for connecting the elongated lines (2) terminates in smooth passages (13) by a shaped plate. small round shovel (14). The outer liner (15) of the stent includes drugs, and in particular the drugs inhibiting cell proliferation, and forms the layer covering the outer surface (16) of the stent. On the other hand, the inner liner accelerates the endothelialization of the stent structure and the reendothelialization of the stent implantation site and includes anti-CD144 monoclonal antibodies and a system for induction of tropomyosin-1 expression. , especially covalent or electrostatic complexes of cell penetration peptides together with the CRISPR / dCas9 system activating the expression of tropomyosin-1 or with expression vectors determining the expression of recombinant human tropomyosin-1, or with stabilized mRNA molecules encoding human tropomyosin-1.
priorityDate 2017-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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