| abstract |
The present invention relates to methods for synthesizing ketones involving an Ni / Zr mediated coupling reaction. Ni / Zr-mediated cetolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C, homohalichondrin A, B, C, norhalichondrin A, B, C), and the like. Therefore, the present invention also relates to synthetic methods useful for the synthesis of halichondrins, and analogs thereof. The invention also relates to compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention relates to methods and compounds useful in the synthesis of a compound of formula (H3-A). |