| abstract |
The present invention provides compositions comprising natural killer (NK) cells that express CD19 and Her2 specific chimeric antigenic receptors (CARs) and a plurality of cell-surface-bound multilamellar liposomal vesicles filled with one or more anti-cancer therapeutic agents at a height. an amount effective to inhibit or kill tumor cells without causing toxicity to NK cells. The invention also relates to methods of using these compositions for treating a subject having a tumor, comprising administering an effective amount of the CAR-manipulated NK cells, wherein an effective amount of anti-tumor therapeutic agents is administered into particles ( for example, cross-linked multilamellar liposomal vesicles) which are bound to the surface of these CAR-manipulated NK cells without causing toxicity to the carrier NK cells. |