| abstract |
The present invention relates to degronimers that include fragments targeting ubiquitin E3 ligase (Degons), which may be linked to a targeting ligand of a protein that has been selected for in vivo degradation, methods of use, and compositions. containing them as well as methods for preparing them.nThe invention also relates to cleavage agents that can be used to treat cereblon-mediated disorders or a protein of the Ikaros family, and methods of use and compositions thereof as well as methods for their preparation. |