| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e422f44e3db6bd55af90f12e772664fc |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-404
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 |
| filingDate |
2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8533fcc56e702511ace7dc4386c22bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46104e50fbfc25a6ddb9eddbeeaeaaac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_216c1079f030fe259658d85867077faf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4055a952cea05623ce5719effd47e367
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3de53dc772a13478af33e9b32de82f1d |
| publicationDate |
2020-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3641758-A1 |
| titleOfInvention |
Compounds for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
| abstract |
Aspects of the present invention include methods of reducing the deleterious impact of a target gene in a cell, such as the deleterious activity of a target gene containing a mutant extended nucleotide repeat (NR) in a cell by contacting the cell with an effective amount of a tetrahydrocarbazolamine compound. The deleterious activity (e.g., the toxicity and / or dysfunction of products encoded thereby) of a target gene containing a mutant extended NR can be reduced, for example, by reducing (and in some cases reducing) differentially, including selectively) the production or activity of toxic expression products (eg, RNA or proteins) encoded by the target gene. The invention also relates to kits and compositions for carrying out the methods of the invention. |
| priorityDate |
2017-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |