http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3640240-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_066af93d226b9a8b1151cb1bc45bd190 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_884a96dc21c42fc594b58fd05e966483 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-34 |
| filingDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96641dfec06692f97431b6bb51c6ac97 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d45731f40562103feeb512e83f1e1178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b9d23a9826ba577a61fbf32a19111f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d94e7858e6cac201f44125e9cad171c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6990942f91d34ef536118ca97a6cdf8 |
| publicationDate | 2020-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3640240-A1 |
| titleOfInvention | Method for purifying ropinirole hydrochloride |
| abstract | Provided is a method for purifying ropinirole hydrochloride (4-2-di-n-propylaminoethyl-1,3-dihydro-2H-indole-2-ketohydrochloride). The method comprises: adding ropinirole hydrochloride containing a monopropyl impurity A into water, adding organic solvent, stirring and dissolving at room temperature, adding alkali, stirring, standing, demixing, and removing an aqueous layer; optionally, drying the organic layer by using anhydrous magnesium sulfate, and filtering; and adding acyl chloride or acid anhydride into the organic layer, stirring, concentrating the organic layer to be dry, adding an organic solvent into the obtained oily substance, adding concentrated hydrochloric acid, and stirring, so as to obtain the ropinirole hydrochloride. By using the method, the impurity A in the ropinirole hydrochloride can be effectively removed, and the ropinirole hydrochloride can be obtained with a high yield and a high purity, so that the impurity A is controlled and the purity of the product reaches a medicinal standard. |
| priorityDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.