| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8828412a08c427cf0e753b98d7339754 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2521-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2511-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2527-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M1-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N13-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0686
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-755 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-755 |
| filingDate |
2012-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_717c5158a13ca60b1e3b97f9b336f27c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74ee5584df4f73f1c5f3f7cb4820bc1d |
| publicationDate |
2020-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3626737-A1 |
| titleOfInvention |
A method of increasing the productivity of eucaryotic cells in the production of recombinant fviii |
| abstract |
A method of increasing the productivity, in particular cell-specific productivity, of recombinant factor VIII (rFVIII) produced in an eukaryotic cell suspension during culturing of said eucaryotic cell suspension in a culturing medium containing not more than 500 µM CaCl<sub>2</sub>, at least a non-ionic detergent and other nutrient components needed for the cells to grow and produce rFVIII, characterized in that the said cell suspension is cultured under conditions inducing a shear stress by mechanical means to the eucaryotic cell suspension by adding power density of at least 3 W/m<sup>3</sup>. |
| priorityDate |
2011-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |