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publicationDate 2020-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3618071-A1
titleOfInvention Methods for selecting tumor-specific neoantigens
abstract Subjects having cancer can be treated in a personalized manner using a patient-specific cocktail of suitable neoantigen or neoepitope peptides and a pharmaceutically acceptable excipient. Selecting suitable neoantigens relies on certain properties of the patient-specific neoantigens predicted or evaluated based on information derived from databases which in turn are derived from prior measurements and observations. Such measurements and observations will be more or less precise and effected to some degree by errors. Thus, the information derived will also be effected by errors to a certain degree. Furthermore, a large number of different properties may need to be taken into account.In this situation, a selection method is suggested providing for an effective treatment at acceptable costs while reducing the influence of any errors in the underlying databases by binning certain descriptors of neoantigen properties and by improved ranking of the neonantigens according to the binning of the descriptors.
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