| abstract |
The present invention relates to piperidine or morpholine linked imidazole and triazole derivatives of formula (I), compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhibiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.n nIn formula(I), especially, W is -N= or -CH=, X is -C(R 3 )(R 4 )- or -S(O) 2 -, and n is 0 or 1 |