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publicationDate 2019-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3574328-A1
titleOfInvention Modular, multifunctional nanoparticle-based bioconjugate for realtime visualization of cellular membrane potential
abstract A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
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